ORAL HYPOGLYCAEMIC AGENTS (OHA): INDICATION FOR USE OF OHA & CONTRAINDICATIONS INDICATION FOR USE OF OHA

Diabetes type -2 patients in whom diabetes is not optimally controlled even with a fair trial of diet and exercise therapy, mostly in middle aged and elderly group, with diabetics of recent origin or without end organ damage.
Maturity onset diabetes of young (MODY)
CONTRAINDICATIONS
Insulin dependant diabetes mellitus
Ketoacidosis
Severe stress : Infection, trauma, major surgery etc.
Severe diabetic state
Malnourished underweight
Severe debilitating
Known allergic to sulphonylurca
Associated endocrinopathies
Impaired hepatic and renal function
ADVANTAGE OF OHA
Easy administration
Cost effective
Acceptability
Less frequent / less severe Hypoglycaemia when compared to insulin therapy
DISADVANTAGE OF ORAL THERAPY
Patient may not seek proper medical supervision
Limitations of dosage and inflexible dosage
Increased incidence of secondary failure with the passage of time
Toxic reaction and drug interaction
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